Transcription profiling of human patients with aortic aneurysms associated with tricuspid and bicuspid valves

ABSTRACT: Patients with bicuspid aortic valve (BAV) have increased risk of thoracic ascending aortic aneurysm (AscAA) and dissection compared to those with a normal tricuspid aortic valve (TAV). The present study was undertaken to evaluate whether differences in gene expression exist in aortas from BAV and TAV patients with AscAA. Experiment Overall Design: Aneurysmal tissue of ascending aorta was collected from 13 patients with bicuspid aortic valve (BAV) and 12 patients with tricuspid aortic valve (TAV). Patients were selected on the basis of aortic diameter, age and other disease conditions. Patients with giant cell aortitis, cardiovascular abnormalities, inherited connective tissue disorders such as Marfan and Ehlers-Danlos syndrome were excluded from the study. RNA was extracted using Invitro

ORGANISM(S): Homo sapiens

SUBMITTER: Ramanath Majumdar 

PROVIDER: E-GEOD-5180 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress