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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Effect of W805EC nanoemulsion (NE) on global gene transcription in JawsII dendritic cells in vitro

ABSTRACT: Nanoemulsion adjuvant affects immune gene expression in dendritic cells. Microarray was used to asses global changes in gene expression in JAWS II dendritic cells upon treatment with nanoemulsion (NE) adjuvant W805EC JawsII cell were incubated with NE formulation for 6 and 24 hours, and RNA was extracted for Affymetrix hybridization

ORGANISM(S): Mus musculus

SUBMITTER: Paul Makidon

PROVIDER: E-GEOD-51804 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effect of W805EC nanoemulsion (NE) on global gene transcription in JawsII dendritic cells in vitro

Project description:Nanoemulsion adjuvant affects immune gene expression in dendritic cells. Microarray was used to asses global changes in gene expression in JAWS II dendritic cells upon treatment with nanoemulsion (NE) adjuvant W805EC

2013-11-09 | GSE51804 | GEO

Transcriptome profiling of NE-4C cells and NE-4C cells with knockdown of Setdb1 by RNA-sequencing

Project description:NE-4C is a mouse neural stem cell line used for study of neuronal differentiation. Setdb1 is an epigenetic modification factor responsible for catalyzing the histone modification H3K9me3. Transcription of Setdb1 gene is enriched in embryonic neural cells during vertebrate embryogenesis. Setdb1 is upregulated in cancer cells and promotes cancers. We found that knockdown of Setdb1 in NE-4C cells led to neuronal differentiation.

2022-06-30 | GSE192373 | GEO

Microarray analysis of the Lysosome-dependent activation of human dendritic cells by the vaccine adjuvant QS-21.

Project description:QS-21 is a component of the Adjuvant System AS01 that is used in several vaccine candidates. QS-21 strongly potentiates both cellular and humoral immune responses to purified antigens, yet how it activates immune cells is largely unknown. Here, QS-21 (or DQ) directly activated human monocyte-derived dendritic cells (moDCs) and promoted a pro-inflammatory transcriptional program.

2017-01-30 | E-MTAB-5388 | biostudies-arrayexpress

Transcriptome profiling of CXCR2+ neuroendocrine (NE) tumor cells purified from patients' fresh prostate adenocarcinoma

Project description:The development of therapy resistance is inevitable in prostate cancer (PCa) despite maximal inhibition of androgen receptor (AR) signaling. Here, we for the first time purified a rare AR-negative NE-cell subset from primary fresh human PCa tissue based on cell-surface receptor CXCR2 and showed that they possess gene signatures of lethal cancer through transcriptional profiling. Functional studies demonstrate CXCR2 to be a driver of NE cells’ key phenotypes, including loss of AR expression, lineage plasticity, and resistance to hormonal-therapy. Furthermore, CXCR2-driven NE cells are critical for the tumor microenvironment by providing a survival niche for the bulk AR+ luminal cells. Importantly, inhibition of CXCR2 by a chemical inhibitor or genetic manipulation dramatically inhibits aggressive PCa cells in-vitro and in-vivo, demonstrating a central role of NE cells in human PCa. Therefore, we firmly established that targeting NE cells through CXCR2 represents a novel, AR-independent therapeutic strategy that will eliminate all tumor cells (NE and luminal), achieving superior therapeutic efficacy.

2019-12-03 | GSE114326 | GEO

Listeria monocytogenes strain:NE dc0214

Project description:Listeria monocytogenes strain:NE dc0214 Genome sequencing

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Gene expression profiling of neuroendocrine (NE) and non-neuroendocrine (non-NE) cells derived from ex vivo cultures of small cell lung cancer (SCLC) circulating tumour cell-derived explant (CDX) model

Project description:To determine molecular processes in vasculogenic mimicry (VM) competent human SCLC CDX, we profiled gene expression by RNA sequencing in separated NE (VM deficient) and non-NE (VM competent) cells from four CDX cultured on plastic or on Matrigel.

2023-10-23 | GSE240789 | GEO

mRNA expression data of Mes vs. Epi cells in mouse non-NE SCLC

Project description:Distinct mRNA populatins have been detected in Epi vs. Mes cells of mouse non-NE SCLC The aim of the study was to globally profile the differential gene expression in Mes vs. Epi cells of mouse non-NE SCLC.

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Expression data from Caco-2 cells expressing TLR4 and associated mutants

Project description:Common missense mutations (D299G, T399I) have been recently identified in the human TLR4 gene. The aim of this study was to determine how TLR4 and associated mutants affect gene expression in Caco-2 cells. We used microarrays to asses gene expression profiles in Caco-2 stably overexpressing TLR4-WT, TLR4-D299G, TLR4-T399I or untransfected. Caco-2 clones stably overexpressing HA-tagged wildtype TLR4-WT, mutant TLR4-D299G or TLR4-T399I were generated. Prior to analysis, cell clones were cultured for 8 days in all experiments. RNA (triplicate) was extracted and hybridized on Affymetrix microarrays.

2011-10-10 | E-GEOD-26226 | biostudies-arrayexpress

NE in Chickens

Project description:16S rRNA amplicon sequence of ileal mucosa bacteria in broiler chickens challenged with NE

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Genome-wide transcriptional changes in the Clostridium perfringens-afflicted chicken intestine in an avian necrotic enteritis (NE) disease model

Project description:This study utilized comparative global gene expression microarray analysis to evaluate the effects of NE on intestinal immunity of chicken. Two-condition experiment, NE-afflicted chickens vs. Non-infected control chickens. Biological replicates: 2 control replicates, 2 NE-afflicted replicates with dye-switching.

2013-09-26 | E-GEOD-51154 | biostudies-arrayexpress

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