Effects on expression profile of acute congestive heart failure (ACHF) patients monocytes by treatment with conventional drugs.

ABSTRACT: Several studies have shown the importance of immune and inflammatory mediators in the pathogenesis of heart failure. In clinical practice has been observed that many conventional drugs can modulate circulating levels of these mediators. Despite, there is poor understanding of the precise mechanisms of these drugs in regulating immune and inflammatory systems. Blood monocytes were isolated from 6 hospitalized patients in Intensive Cardiology Care Unit (ICCU) with symptomatic acute congestive heart failure (ACHF) (NYHA Class III-IV) before and after treatment with conventional drugs (ARBs, ACEIs, diuretics, and beta-blockers). Gene expression analysis (n=11) using whole human genome microarray showed that pharmacological treatment abrogate inflammatory activation of monocytes. The inflammato

ORGANISM(S): Homo sapiens

SUBMITTER: Mirko Pesce 

PROVIDER: E-GEOD-51888 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress