Long noncoding RNA expression in several hematopoietic progenitor and differentiated cell populations using a custom Agilent microarray

ABSTRACT: Mammals express thousands of long noncoding (lnc) RNAs, a few of which are shown to function in tissue development. However, the entire repertoire of lncRNAs and the extent to which they regulate biological processes in different tissues and species are not defined. Indeed, most lncRNAs are not conserved between species, raising questions about function. We used RNA-Seq to identify lncRNAs in primary murine fetal liver erythroblasts expressing the lineage marker TER119, megakaryocytes (CD41+) cultured from embryonic day (E) 14.5 murine fetal liver and megakaryocyte erythroid progenitors (MEPs) isolated from mouse bone marrow. We identified 683 and 594 polyadenylated lncRNAs expressed in red blood cell (erythroid) precursors of mice and humans, respectively. More than one half of erythroid

ORGANISM(S): Mus musculus

SUBMITTER: Ross Hardison 

PROVIDER: E-GEOD-51892 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress