Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Kadir Akdemir
PROVIDER: E-GEOD-51929 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cancer discovery 20151008 12
<h4>Unlabelled</h4>Epigenetic regulators have emerged as critical factors governing the biology of cancer. Here, in the context of melanoma, we show that RNF2 is prognostic, exhibiting progression-correlated expression in human melanocytic neoplasms. Through a series of complementary gain-of-function and loss-of-function studies in mouse and human systems, we establish that RNF2 is oncogenic and prometastatic. Mechanistically, RNF2-mediated invasive behavior is dependent on its ability to monoub ...[more]