MicroRNA differential regulations gradually mediate genomic instability during cervical intraepithelial neoplasia progression.

ABSTRACT: In most cases human papillomavirus (HPV) infections are cleared from the cervical cells by the immune system itself, but in a few cases, where there is persistent HPV infection, it can lead to cervical intraepithelial neoplasia (CIN) progression and ultimately invasive cervical carcinoma. The cytopathic effect is in general accompanied by chronic inflammation, which produces inflammation cytokines that contribute to DNA damage, and at the same time, aberrations occurred in the host DNA repair mechanisms, thus lead to HPV genomic integration into the host cells which propels cell immortalization. In this study, we reported the genome-wide expression profiles of both microRNAs (miRNAs) and mRNAs from 24 cervical samples with consecutive stages of normal, CIN I (mild dysplasia) and CIN III (s

ORGANISM(S): Homo sapiens

SUBMITTER: Wenjuan Mo 

PROVIDER: E-GEOD-51993 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress