Transcription profiling of mouse macrophages infected with B. melitensis

ABSTRACT: Facultative intracellular Brucella infect and survive inside macrophages, and the outcome of macrophage-Brucella interaction is a basis for establishment of a chronic Brucella infection. The majority of Brucella are killed at the early infection stage. A subpopulation of virulent Brucella strains is instead trafficked to an intracellular replicative phagosome, and are resistant to further attack and begin to multiply dramatically. Virulent Brucella also inhibit macrophage apoptosis that in turn favors pathogen survival and replication. We used the Affymetrix mouse GeneChip 430 2.0 array to analyze mouse macrophage gene expression profiles during the time course of virulent B. melitensis strain 16M infection. Experiment Overall Design: Murine J774.A1 macrophage cells were infected with B. m

ORGANISM(S): Mus musculus

SUBMITTER: Yongqun He 

PROVIDER: E-GEOD-5202 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress