Dataset Information
5'RNA-seq analysis of hypertrophic cardiomyopathy (HCM) in mice that carry a human missence mutation in the myosin heavy chain
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Jonathan Seidman
PROVIDER: E-GEOD-52038 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy.
The Journal of clinical investigation 20140210 3
The transcriptome is subject to multiple changes during pathogenesis, including the use of alternate 5' start-sites that can affect transcription levels and output. Current RNA sequencing techniques can assess mRNA levels, but do not robustly detect changes in 5' start-site use. Here, we developed a transcriptome sequencing strategy that detects genome-wide changes in start-site usage (5'RNA-Seq) and applied this methodology to identify regulatory events that occur in hypertrophic cardiomyopathy ...[more]
