Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

ABSTRACT: TNF is a proinflammatory cytokine with established roles in host defense and immune system organogenesis. Here we report a novel physiological function of TNF that extends its effect beyond the host into the developing offspring. A partial/complete maternal TNF-deficit, specifically in hematopoietic cells, resulted in reduced milk levels of chemokines IP-10, MCP-1/-3/-5, and MIP-1β, which in turn, augmented offspring postnatal hippocampal proliferation, leading to improved adult spatial memory. These effects were reproduced by the postpartum administration of a clinically used anti-TNF agent. Chemokines, fed to suckling pups of TNF-deficient mothers, restored both postnatal proliferation and adult spatial memory to normal levels. This work identifies a TNF-dependent “lactrocrine” path

ORGANISM(S): Mus musculus

SUBMITTER: Shifra Klein 

PROVIDER: E-GEOD-52069 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress