Profiling and bioinformatics analysis of hsa-miRNAs involved in A549 strain of human alveolar epithelial type II cell line infected with A/Zhejiang/DTID-ZJU02/2009(H1N1)

ABSTRACT: A/Zhejiang/DTID-ZJU02/2009(H1N1) is a strain of the swine-origin influenza A(H1N1) virus isolated during the human swine flu outbreak of 2009. To analyze the miRNA expression profiles of A549 cells infected with A/Zhejiang/DTID-ZJU02/2009(H1N1) at 0, 24, 48, and 72 h post-infection (hpi) and investigate the relation between the miRNA expression profile and its pathogenesis, Human MicroRNA Array v2.0 was applied. At 24 hpi, 174 miRNAs were detected to change their expression compared with 0 hpi, 28 of them increased and 146 decreased. At 48 hpi, 214 changed miRNAs were detected, 21 of them increased and 193 decreased. At 72 hpi, 282 changed miRNAs were detected, 19 of them increased and 263 decreased. Targets of the 21 significantly differentially expressed miRNAs were analyzed by bioinform

ORGANISM(S): Homo sapiens

SUBMITTER: Li Dengyun 

PROVIDER: E-GEOD-52105 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress