Deletion of conserved protein phosphatases reverses defects associated with mitochondrial DNA damage in Saccharomyces cerevisiae

ABSTRACT: Mitochondrial biogenesis is regulated by signaling pathways sensitive to extracellular conditions and to the internal environment of the cell. We found that deletion of protein phosphatase 2A (PP2A) or of protein phosphatase 6 (PP6) diminishes the nuclear transcriptional response associated with mtDNA damage. Six samples were analyzed to determine message RNA levels.

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Cory Dunn 

PROVIDER: E-GEOD-52242 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress