Parsing the roles of transcription factors Gata4 and Gata6 in adult cardiac hypertrophic responses

ABSTRACT: Cardiac hypertrophy is regulated by the zinc finger-containing DNA binding factors Gata4 and Gata6, both of which are required to mount a productive growth response of the adult heart. To determine if Gata4 and Gata6 are redundant or have non-overlapping roles, we performed cardiomyocyte-specific conditional gene deletions for Gata4 and Gata6 in conjunction with reciprocal replacement with a transgene encoding either Gata4 or Gata6, during the pressure overload response. We determined that Gata4 and Gata6 play a redundant and dosage-sensitive role in programming the hypertrophic growth response itself following pressure overload stimulation. However, non-redundant functions were identified as functional decompensation induced by either Gata4 or Gata6 deletion was not rescued by the recip

ORGANISM(S): Mus musculus

SUBMITTER: Bruce Aronow 

PROVIDER: E-GEOD-52317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress