Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin-A (BoNT-A)

ABSTRACT: Introduction:The purpose of this study is to provide athe first global transcriptomic profiling and systems analysis of BoNT-A treated muscle over a one year period. Microarray analysis was performed on rat TA muscle from 4 groups (n=4/group) at 1,4, 12 and 52 weeks after BoNT-A injection and saline injected rats at 12 weeks as control. Fold changes were computed at each time point with respect to control. Results: Dramatic transcriptional adaptation occurs at 1 week with a paradoxical increase in expression of slow and immature isoforms; increased expression of genes in competing pathways of repair and atrophy; impaired mitochondrial biogenesis and increased metal ion imbalance. ECM adaptations occurred at 4weeks to the basal lamina and fibrillar ECM. The muscle transcriptome returned to

ORGANISM(S): Rattus norvegicus

SUBMITTER: Kavitha Mukund 

PROVIDER: E-GEOD-52350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress