Aorta- and liver-specific ERalpha binding patterns and gene regulation by estrogen (ChIP-seq)

ABSTRACT: Estrogen has vascular protective effects in premenopausal women and in women under 60 receiving hormone replacement therapy. However, estrogen also increases risks of breast and uterine cancers and of venous thromboses linked to upregulation of coagulation factors in the liver. In mouse models, the vasoprotective effects of estrogen are mediated by the estrogen receptor alpha (ERa) transcription factor. Here, through next generation sequencing approaches, we show that almost all of the genes regulated by 17-b-estradiol (E2) differ between mouse aorta and mouse liver, and that this is associated with a distinct genomewide distribution of ERa on chromatin. Bioinformatic analysis of E2-regulated promoters and ERa binding site sequences identify several transcription factors that may determine

ORGANISM(S): Mus musculus

SUBMITTER: Gavin Schnitzler 

PROVIDER: E-GEOD-52351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress