Identification of a CD271-associated signaling network in human malignant melanoma cells

ABSTRACT: Background: Large-scale genomic analyses of patient cohorts have revealed extensive heterogeneity between individual tumors, contributing to treatment failure and drug resistance. In malignant melanoma, heterogeneity is thought to arise as a consequence of the differentiation of melanoma-initiating cells that are defined by cell-surface markers like CD271 or CD133. Results: Here we identified the nerve growth factor receptor (CD271) as a crucial determinant of melanoma cell tumorigenicity, stem-like properties, heterogeneity and plasticity. Stable shRNA mediated knock-down of CD271 in patient-derived melanoma cells abrogated their tumor-initiating and colony-forming capacity. A genome-wide expression profiling and gene-set enrichment analysis revealed novel connections of CD271 with melano

ORGANISM(S): Homo sapiens

SUBMITTER: Torben Redmer 

PROVIDER: E-GEOD-52456 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress