Clustering of tissue-specific sub-TADs accompanies the regulation of HoxA genes in developing limbs

ABSTRACT: HoxA genes exhibit central roles during development and causal mutations have been found in several human syndromes including limb malformation. Despite their importance, information on how these genes are regulated is lacking. Here, we report on the first identification of bona fide transcriptional enhancers controlling HoxA genes in developing limbs and show that these enhancers are grouped into distinct topological domains at the sub-megabase scale (sub-TADs). We provide evidence that target genes and regulatory elements physically interact with each other through contacts between sub-TADs rather than by the formation of discreet "DNA loops". Interestingly, there is no obvious relationship between the functional domains of the enhancers within the limb and how they are part

ORGANISM(S): Mus musculus

SUBMITTER: Soizik Berlivet 

PROVIDER: E-GEOD-52483 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress