Gene signature predictive of response to chemotherapy in mCRC [RT-PCR]

ABSTRACT: The objective is to generate a robust and validated predictor profile for chemotherapy response in patients with mCRC using microarray gene expression profiles of primary colorectal cancer tissue. To define a gene signature of response to chemotherapy in metastatic colorectal cancer, samples were obtained from 40 patients from Marques de Valdecilla Hospital who underwent primary surgery. Gene expression was detected and quantified using the Human Whole Genome U133 Plus 2.0 array (Affymetrix), containing 54675 human gene probes. The validation set consisted of 119 samples from Hospital Virgen del Rocio, Seville, Spain; Hospital Virgen de la Victoria, Malaga, Spain; Hospital de la Merced, Osuna, Spain and Hospital MarquM-CM-)s de Valdecilla, Santander, Spain, and included 86 tumor samples (4

ORGANISM(S): Homo sapiens

SUBMITTER: Purificacion Estevez-Garcia 

PROVIDER: E-GEOD-52513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress