Genome-wide methylation profiling of multiple sporadic colorectal cancer

ABSTRACT: Background an Aim: Epigenetics are thought to play a major role in the carcinogenesis of patients that develop multiple colorectal cancers (CRC) in the non-hereditary setting. Previous studies have suggested concordant DNA hypermethylation between tumor pairs. However, only a few methylation markers have been analyzed. This study was aimed at describing the underlying epigenetic signature that differentiates multiple from solitary colorectal cancer tumors using a genome-scale DNA methylation profiling. Patients and Methods: We used a population-based cohort (EPICOLON II) of 12 patients with synchronous CRC and 29 age- sex- and tumor location-paired solitary CRC patients. DNA methylation profiling was performed using the Illumina Infinium HM27 DNA methylation assay. The most significantly

ORGANISM(S): Homo sapiens

SUBMITTER: Juanjo Lozano 

PROVIDER: E-GEOD-52573 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress