Early SIV infection and effects of pathogenic and commensal enteric bacteria on expression in ileum tissue

ABSTRACT: We used the ileal loop model to assess the effects of enteric bacteria organisms on host gene expression in intestinal tissue independent of and following early SIV infection. SIV infection in the gut causes rapid and severe immune dysfunction and damage to the intestinal structure, this may alter the intimate interaction with lumenal organisms. This study was performed to determine whether early SIV infection, prior to the depletion of CD4+ T cells, can alter interaction of the host with pathogenic Salmonella serovar Typhimurium (ST) or commensal Lactobacillus plantarum (LP), and to further understand the earliest changes to the intestinal mucosa following SIV infection. We used microarray analysis to detail the global program of gene expression underlying changes in the ileum following e

ORGANISM(S): Macaca mulatta

SUBMITTER: Satya Dandekar 

PROVIDER: E-GEOD-52589 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress