Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)

ABSTRACT: Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known to suppress tumor formation in several cancer types, we found that leukemia cells instead rely on Brg1 to support their oncogenic transcriptional program, which includes Myc as one of its key targets. To account for this context-specific function, we identify a cluster of lineage-specific enhancers located 1.7 megabases downstream of Myc that are occupied by SWI/SNF, as well as the BET protein Brd4. Brg1 is required at these distal elements to maintain transcription factor occupancy and for lon

ORGANISM(S): Mus musculus

SUBMITTER: Christopher Vakoc 

PROVIDER: E-GEOD-52595 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress