Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

14 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Runx3 Regulates Interleukin-15-Dependent Natural Killer Cell Activation

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Joseph Lotem

PROVIDER: E-GEOD-52625 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.

Levanon Ditsa D Negreanu Varda V Lotem Joseph J Bone Karen Rae KR Brenner Ori O Leshkowitz Dena D Groner Yoram Y

Molecular and cellular biology 20140113 6

Natural killer cells belong to the family of innate lymphoid cells comprising the frontline defense against infected and transformed cells. Development and activation of natural killer cells is highly dependent on interleukin-15 signaling. However, very little is known about the transcription program driving this process. The transcription factor Runx3 is highly expressed in natural killer cells, but its function in these cells is largely unknown. We show that loss of Runx3 impaired interleukin- ...[more]

PMID: 24421391

Similar Datasets

Runx3 function in splenic NK cells activated in vivo by IL-15.

Project description:NK cells are innate immune cells that recognize and kill foreign, virally-infected and tumor cells without the need for prior immunization. NK expansion following viral infection is IL-2 or IL-15-dependent. To identify Runx3 regulated genes, NK cells were isolated from spleen of IL15/Ra injected WT and Runx3-/- mice and sorted to obtain 3 subpopulations of immature (CD27) and mature (DP and CD11c) NK cells.

2014-01-22 | E-GEOD-50120 | biostudies-arrayexpress

Genome-wide maps of Runx3 bound regions in splenic NK cells activated in vivo with IL-15

Project description:ChIP-seq was conducted using freshly isolated splenic WT NK cells from IL-15/Ra treated mice with anti-Runx3 antibody (Ab) and non-immune serum (NIS) as control. Runx3 and NIS IP from splenic NK cells of IL-15/Ra treated WT mice, isolated by negative selection using NK cell isolation kit (R&D) followed by sorting of NKp46+ cells.

2014-01-22 | E-GEOD-50126 | biostudies-arrayexpress

Genome-wide maps of Runx3 bound regions in splenic NK cells

Project description:ChIP-seq was conducted using freshly isolated (resting) splenic WT NK cells with anti-Runx3 antibody (Ab), anti-H3K4me1 Ab and non-immune serum (NIS) as control. Runx3 and H3K4me1 IP from splenic NK cells isolated by negative selection using NK cell isolation kit (R&D) followed by sorting of NKp46+ cells.

2013-11-18 | E-GEOD-50127 | biostudies-arrayexpress

Genome-wide maps of Runx3 bound regions in IL-2-activated splenic NK cells

Project description:ChIP-seq was conducted using splenic WT NK cells cultured for 7 days with IL-2 using anti-Runx3 antibodies (Ab), anti-H3K4me1 Ab and non-immune serum (NIS) as control. Two biological Runx3, one H3K4me1 and two NIS IP repeats from splenic NK cells isolated from individual mice by negative selection using NK cell isolation kit (R&D) cultured with IL-2.

2013-11-18 | E-GEOD-50129 | biostudies-arrayexpress

The transcription program of Runx3 in natural killer cells and CD8+ T cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-11-18 | E-GEOD-50131 | biostudies-arrayexpress

Genome-wide maps of Runx3 bound regions in splenic CD8+ T cells.

Project description:ChIP-seq was conducted using freshly isolated (resting) splenic WT CD8+ T cells with anti-Runx3 antibody (Ab), anti-H3K4me1 Ab and non-immune serum (NIS) as control. Two biological Runx3 and two NIS IP repeats from splenic CD8+ T cells isolated by positive selection on anti-CD8 magnetic beads, collected from 18 WT mice.

2013-11-18 | E-GEOD-50130 | biostudies-arrayexpress

RNA-seq of group 1 Innate Lymphoid Cells (ILCs) in the mouse uterus and liver

Project description:We identified differences in the distribution of three group 1 ILC subsets in the mouse uterus. The dynamic distribution of g1 ILC subsets in the uterus at key stages of reproductive life may reflect subset-specific functions and emphasised the need for detailed characterisation of each subset

2018-10-05 | E-MTAB-6812 | biostudies-arrayexpress

Runx3 regulated genes in splenic CD4+ dendritic cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-06-22 | E-GEOD-48591 | biostudies-arrayexpress

Genome-wide maps of Runx3 bound regions in splenic IL-2-activated CD8+ T cells

Project description:ChIP-seq was conducted on isolated splenic WT CD8+ T cells, TCR-activated and cultured with IL-2 using anti-Runx3 antibodies (Ab), anti-H3K4me1 Ab and non-immune serum (NIS) as control. Two biological Runx3 and two NIS IP repeats from TCR-activated and IL-2 cultured splenic CD8+ T cells isolated by positive selection on anti-CD8 magnetic beads.

2013-11-18 | E-GEOD-50128 | biostudies-arrayexpress

scRNAseq of the bone marrow immune microenvironment in control and 5TGM1 myeloma-bearing C57Bl/6 and KaLwRij mice

Project description:We hypothesized that the immune microenvironment of the bone marrow influences the progression of myeloma outgrowth in the 5TGM1 transfer model of multiple myeloma. Therefore we sorted bone marrow T, B, NK, neutrophils, and monocytes/macrophages from control and tumor-bearing C57Bl/6 and KaLwRij mice.

2023-02-23 | E-MTAB-12616 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data