Gene expression profiling of miR27a over-expressing RH36 cell lines.
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Gerolamo Lanfranchi
PROVIDER: E-GEOD-52678 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
MicroRNA-27a Contributes to Rhabdomyosarcoma Cell Proliferation by Suppressing RARA and RXRA.
Tombolan Lucia L Zampini Matteo M Casara Silvia S Boldrin Elena E Zin Angelica A Bisogno Gianni G Rosolen Angelo A De Pittà Cristiano C Lanfranchi Gerolamo G
PloS one 20150427 4
<h4>Background</h4>Rhabdomyosarcomas (RMS) are rare but very aggressive childhood tumors that arise as a consequence of a regulatory disruption in the growth and differentiation pathways of myogenic precursor cells. According to morphological criteria, there are two major RMS subtypes: embryonal RMS (ERMS) and alveolar RMS (ARMS) with the latter showing greater aggressiveness and metastatic potential with respect to the former. Efforts to unravel the complex molecular mechanisms underlying RMS p ...[more]
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