Transcription profiling of human bronchoalveolar to investigate airway inflammatory cell response to lipopolysaccharide and house dust mite antigen

ABSTRACT: Allergic asthmatic, allergy only, asthma only (no allergy), and non-allergic non-asthmatic (control) subjects underwent bronchoscopy with instillation of saline, lipopolysaccharide (LPS), and house dust mite antigen in separate subsegmental bronchi. Bronchoalveolar lavage (BAL) fluid was collected four hours later (three samples per subject). Inflammatory cells from each specimen were isolated and RNA was extracted for microarray analysis. Experiment Overall Design: There are four main phenotypic groups: Experiment Overall Design: 1. control (no allergy or asthma) Experiment Overall Design: 2. allergy only (no asthma) Experiment Overall Design: 3. asthma only (no allergy) Experiment Overall Design: 4. allergy and asthma Experiment Overall Design: and three exposures: saline, house dust mit

ORGANISM(S): Homo sapiens

SUBMITTER: John Tomfohr 

PROVIDER: E-GEOD-5272 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress