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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from E12.5 and E14.5 mouse embryonic gonad of wild type (WT) and Wnt-4 knock-out (KO) mice.

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

ORGANISM(S): Mus musculus

SUBMITTER: Florence Naillat

PROVIDER: E-GEOD-52730 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary.

Naillat Florence F Yan Wenying W Karjalainen Riikka R Liakhovitskaia Anna A Samoylenko Anatoly A Xu Qi Q Sun Zhandong Z Shen Bairong B Medvinsky Alexander A Quaggin Susan S Vainio Seppo J SJ

Experimental cell research 20150130 2

The indifferent mammalian embryonic gonad generates an ovary or testis, but the factors involved are still poorly known. The Wnt-4 signal represents one critical female determinant, since its absence leads to partial female-to-male sex reversal in mouse, but its signalling is as well implicated in the testis development. We used the Wnt-4 deficient mouse as a model to identify candidate gonadogenesis genes, and found that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovar ...[more]

PMID: 25645944

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