Molecular Specificity, Convergence and Constraint Shape Adaptive Evolution in Nutrient-Poor Environments [GE]

ABSTRACT: One of the central goals of evolutionary biology is to explain and predict the molecular basis of adaptive evolution. We studied the evolution of genetic networks in Saccharomyces cerevisiae (budding yeast) populations propagated for more than 200 generations in different nitrogen-limiting conditions. We find that rapid adaptive evolution in nitrogen-poor environments is dominated by the de novo generation and selection of copy number variants (CNVs), a large fraction of which contain genes encoding specific nitrogen transporters including PUT4, DUR3 and DAL4. The large fitness increases associated with these alleles limits the genetic heterogeneity of adapting populations even in environments with multiple nitrogen sources. Complete identification of acquired point mutations, in individua

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Jungeui Hong 

PROVIDER: E-GEOD-52786 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress