The Lung Microbiome of HIV-infected Pneumonia Patients in Sub-Saharan Africa

ABSTRACT: Sub-Saharan Africa represents 69% of the total number of individuals living with HIV infection worldwide and 72% of AIDS deaths globally. Pulmonary infection is a common and frequently fatal complication, though little is known regarding the lower airway microbiome composition of this population. Our objectives were to characterize the lower airway microbiome of Ugandan HIV-infected patients with pneumonia, to determine relationships with demographic, clinical, immunological, and microbiological variables and to compare the composition and predicted metagenome of these communities to a comparable cohort of patients in the US (San Francisco). Bronchoalveolar lavage samples from a cohort of 60 Ugandan HIV-infected patients with acute pneumonia were collected. Amplified 16S ribosomal RNA was

ORGANISM(S): Homo sapiens

SUBMITTER: Shoko Iwai 

PROVIDER: E-GEOD-52791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress