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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Gene Expression Analysis of PDAC tumors

ABSTRACT: Analysis of myofibroblast ablation at the gene expression level of PDAC tumors. Total RNA optained from pancreas of PDAC mice with and without aSMA myofibroblast ablated In addition, late stage aSMA ablated mice were treated with anti-CTLA4 treatment

ORGANISM(S): Mus musculus

SUBMITTER: Valerie LeBleu

PROVIDER: E-GEOD-52812 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival.

Özdemir Berna C BC Pentcheva-Hoang Tsvetelina T Carstens Julienne L JL Zheng Xiaofeng X Wu Chia-Chin CC Simpson Tyler R TR Laklai Hanane H Sugimoto Hikaru H Kahlert Christoph C Novitskiy Sergey V SV De Jesus-Acosta Ana A Sharma Padmanee P Heidari Pedram P Mahmood Umar U Chin Lynda L Moses Harold L HL Weaver Valerie M VM Maitra Anirban A Allison James P JP LeBleu Valerie S VS Kalluri Raghu R

Cancer cell 20140522 6

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the ability to delete αSMA(+) myofibroblasts in pancreatic cancer were generated. Depletion starting at either noninvasive precursor (pancreatic intraepithelial neoplasia) or the PDAC stage led to invasive, undifferentiated tumors with enhanced hypoxia, epithelial-to-mesenchymal transition, and cancer stem cells, with dimin ...[more]

PMID: 24856586

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