Bcl11a (Ctip1) controls migration of cortical projection neurons through regulation of Sema3c

ABSTRACT: During neocortical development, neurons undergo polarization, oriented migration, and layer type-specific differentiation. The transcriptional programs underlying these processes are not completely understood. Here we show that the transcription factor Bcl11a regulates polarity and migration of upper layer neurons. Bcl11a-deficient late-born neurons fail to correctly switch from multipolar to bipolar morphology resulting in impaired radial migration. We show that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription. In vivo gain-of-function and rescue experiments demonstrate that Sema3c is a major downstream effector of Bcl11a required for the cell polarity switch and for the migration of upper la

ORGANISM(S): Mus musculus

SUBMITTER: Karlheinz Holzmann 

PROVIDER: E-GEOD-52827 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress