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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton’s jelly derived Mesenchymal Stem Cells [set1]

ABSTRACT: In order to identify gene-expression patterns in mesenchymal stem cells associated with different birth weights and intrauterine growth parameters, we conducted comparative microarray gene expression experiments prior and post acute insulin stimulation Samples were collected from umbilical cord derived mesenchymal stem cells (UC-MSC). 4 samples belong to SGA (Small for Gestational Age) and 4 samples belong to control group

ORGANISM(S): Homo sapiens

SUBMITTER: Joanna Holbrook

PROVIDER: E-GEOD-52841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Molecular pathways reflecting poor intrauterine growth are imprinted in WhartonM-bM-^@M-^Ys jelly derived Mesenchymal Stem Cells [Set2]

Project description:In order to identify gene-expression patterns in mesenchymal stem cells associated with different birth weights and intrauterine growth parameters, we conducted comparative microarray gene expression experiments prior and post acute insulin stimulation Mesenchymal stem cells (MSC) were extracted from the Wharton's jelly of the umbilical cord of normal and SGA babies. The MSCs were expended in culture. The MSCs were subjected to acute insulin treatment for various time points. The RNA of these cells were collected for gene-expression study.

2014-03-31 | E-GEOD-52842 | biostudies-arrayexpress

Molecular pathways reflecting poor intrauterine growth are imprinted in WhartonM-bM-^@M-^Ys jelly derived Mesenchymal Stem Cells [set4]

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Molecular pathways reflecting poor intrauterine growth are imprinted in WhartonM-bM-^@M-^Ys jelly derived Mesenchymal Stem Cells [set3]

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Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton's jelly derived Mesenchymal Stem Cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-03-31 | E-GEOD-52845 | biostudies-arrayexpress

Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton’s jelly derived Mesenchymal Stem Cells [set1]

2014-03-31 | GSE52841 | GEO

Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton’s jelly derived Mesenchymal Stem Cells [set4]

2014-03-31 | GSE52844 | GEO

Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton’s jelly derived Mesenchymal Stem Cells [set3]

2014-03-31 | GSE52843 | GEO

Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton’s jelly derived Mesenchymal Stem Cells [Set2]

2014-03-31 | GSE52842 | GEO

Molecular pathways reflecting poor intrauterine growth are imprinted in Wharton's jelly derived Mesenchymal Stem Cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2014-03-31 | GSE52845 | GEO

E2F1 orchestrates transcriptomics and oxidative metabolism in Wharton’s jelly derived mesenchymal stem cells from growth-restricted neonates

Project description:Wharton’s jelly derived Mesenchymal Stem Cells (MSCs) isolated from newborns with intrauterine fetal growth restriction were previously shown to exert anabolic features including insulin hypersensitivity. Here, we extend these observations and demonstrate that MSCs from small for gestational age (SGA) individuals have decreased mitochondrial oxygen consumption rates. Comparing normally grown and SGA MSCs using next generation sequencing studies, we measured global transcriptomic and epigenetic profiles and identified in SGA, E2F1 as an over-expressed transcription factor regulating oxidative metabolism. We further show that E2F1 regulates the differential transcriptome found in SGA and is associated with the activating histone marks H3K27ac and H3K4me3. One of the key genes regulated by E2F1 was found to be the fatty acid elongase ELOVL2, a gene involved in the endogenous synthesis of docosahexaenoic acid (DHA).

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