Transcriptomic analysis of neuroblastoma SH-SY5Y cells in response to stable over-expression of histone H2A type 2-B

ABSTRACT: Neuroblastoma is the most common extracranial solid malignancy derived from neural crest cells. Better elucidation of the mechanisms underlying the aggressive progression of neuroblastoma is needed for improving the therapeutic efficiencies. Since previous studies indicate that histone H2A type 2-B (H2AB), a histone H2A variant locating at chromosome 1q21.2 region, is up-regulated in neural progenitor cells and early motor neurons, we hypothesized that H2AB might participate in the progression of neuroblastoma. We employed the human whole genome microarray expression profiling as a discovery platform to analyze the transcriptome profiling changes of human neuroblastoma SH-SY5Y cells in response to stable over-expression of H2AB. The results showed that stable over-expression of H2AB led to

ORGANISM(S): Homo sapiens

SUBMITTER: Qiangsong Tong 

PROVIDER: E-GEOD-52852 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress