Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Didier Devys
PROVIDER: E-GEOD-52860 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Genes & development 20140901 18
The SAGA (Spt-Ada-Gcn5 acetyltransferase) coactivator complex contains distinct chromatin-modifying activities and is recruited by DNA-bound activators to regulate the expression of a subset of genes. Surprisingly, recent studies revealed little overlap between genome-wide SAGA-binding profiles and changes in gene expression upon depletion of subunits of the complex. As indicators of SAGA recruitment on chromatin, we monitored in yeast and human cells the genome-wide distribution of histone H3K9 ...[more]