Early pre-symptomatic and progressive signatures of non-coding RNAs in ALS patients and mutation carriers

ABSTRACT: Knowledge about the nature and timepoint of pathomolecular alterations preceding onset of symptoms in amyotrophic lateral sclerosis (ALS) is largely lacking. It could not only pave the way for valuable therapeutic targets but might also govern future concepts of pre-manifest disease modifying treatments. MicroRNAs (miRNAs) are central regulators of transcriptome plasticity and participate in pathogenic cascades and/or mirror cellular adaptation to insults. We obtained expression profiles of miRNAs as well as other non-coding RNAs (ncRNAs) in the serum of sporadic ALS patients (sALS), familial ALS cases (fALS), asymptomatic mutation carriers and healthy controls. We observed a strikingly homogenous ncRNA profile in fALS patients that, to a large extend, was independent to the underlying dis

ORGANISM(S): Homo sapiens

SUBMITTER: Karlheinz Holzmann 

PROVIDER: E-GEOD-52917 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress