Targeting Csnk1a1 induces selective p53-dependant killing of leukemia stem cells

ABSTRACT: We found found that casein kinase 1 alpha (Csnk1a1), a serine threonine kinase and negative regulator of beta catenin, is essential for leukemia cells in vivo. We examined the effect of Csnk1a1 knowckdown by gene expression profiling in primary leukemia cells.

ORGANISM(S): Mus musculus

SUBMITTER: Fatima Al-Shahrour 

PROVIDER: E-GEOD-52928 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress