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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene

ABSTRACT: To examine the NRF2 activity in anaplastic glioma with mutated IDH1/2, we conducted the microarray analysis to measure the expression levels of representative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2.

ORGANISM(S): Homo sapiens

SUBMITTER: Masayuki Kanamori

PROVIDER: E-GEOD-52942 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients.

Kanamori Masayuki M Higa Tsuyoshi T Sonoda Yukihiko Y Murakami Shohei S Dodo Mina M Kitamura Hiroshi H Taguchi Keiko K Shibata Tatsuhiro T Watanabe Mika M Suzuki Hiroyoshi H Shibahara Ichiyo I Saito Ryuta R Yamashita Yoji Y Kumabe Toshihiro T Yamamoto Masayuki M Motohashi Hozumi H Tominaga Teiji T

Neuro-oncology 20141010 4

<h4>Background</h4>Nuclear factor erythroid 2-related factor 2 (NRF2) plays pivotal roles in cytoprotection. We aimed at clarifying the contribution of the NRF2 pathway to malignant glioma pathology.<h4>Methods</h4>NRF2 target gene expression and its association with prognosis were examined in 95 anaplastic gliomas with or without isocitrate dehydrogenase (IDH) 1/2 gene mutations and 52 glioblastomas. To explore mechanisms for the altered activity of the NRF2 pathway, we examined somatic mutatio ...[more]

PMID: 25304134

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Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene

Project description:To examine the NRF2 activity in anaplastic glioma with mutated IDH1/2, we conducted the microarray analysis to measure the expression levels of representative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1.

2013-12-04 | GSE52942 | GEO

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Metabolic changes related to the IDH1 mutation in gliomas preserve TCA-cycle activity: an investigation at the protein level

Project description:The discovery of the IDH1 R132H (IDH1 mut) mutation in low-grade glioma and the associated change in function of the IDH1 enzyme has increased the interest in glioma metabolism. In an earlier study, we found that changes in expression of genes involved in the aerobic glycolysis and the TCA-cycle are associated with IDH1 mut. Here we apply proteomics to FFPE samples of diffuse gliomas with or without IDH1 mutations, in order to map changes in protein levels associated with this mutation. We observed significant changes in the enzyme abundance associated with aerobic glycolysis, glutamate metabolism and the TCA-cycle in IDH1 mut gliomas. Specifically, the enzymes involved in the metabolism of glutamate, lactate and enzymes involved in the conversion of α-ketoglutarate were increased in IDH1 mut gliomas. In addition, the bicarbonate transporter (SLC4A4) was increased in IDH1 mut gliomas, supporting the idea that a mechanism preventing intracellular acidification is active. We also found that enzymes that convert proline, valine, leucine and isoleucine into glutamate were increased in IDH1 mut glioma. We conclude that in IDH1 mut glioma metabolism is rewired (increased input of lactate and glutamate) to preserve TCA cycle activity in IDH1 mut gliomas.

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Project description:Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene

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Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma

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Project description:A natural product algal extract and its major component, cymopol, have demonstrated anti-oxidant and anti-inflammatory activity in vitro and in vivo. RNA transcript levels of Nqo1 and Hmox1 were discovered in multiple organs following oral gavage of 2 doses of the extract and cympopol for 3 consecutive days. The highest change in gene expression was noted in the digestive tract.

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Project description:Comparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene

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