Using breast (cancer) cell lines to measure bortezomib therapy response

ABSTRACT: Revealing targeted therapy for human cancer by gene module maps A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading to improved prognostic predictions. However, how these new genetic subtypes of cancers should be treated is unknown. Here we show that a gene module map can guide the prospective identification of targeted therapies for genetic subtypes of cancer. By visualizing genome-scale gene expression in cancer as combinations of activated and deactivated functional modules, gene module maps can reveal specific functional pathways associated with each subtype that might be susceptible to targeted therapie

ORGANISM(S): Homo sapiens

SUBMITTER: Dimitry Nuyten 

PROVIDER: E-GEOD-5307 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress