Transcription profiling of mouse mammary gland side population cells (MG-SPs) to identify differentially expressed genes.

ABSTRACT: Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) that describes genes in terms of biological processes and ontology traverser (OT) that performs enrichment analysis were utilized. OT showed that MG-SP specific genes were enriched in the GO categories of cell cycle regulation and checkpoints, multi-drug resistant transporters, organogenesis, and vasculogenesis. The MG-NSP upregulated genes were enriched in the GO category of cellular organization and biogenesis which includes basal epithelial markers, p63, smooth muscle actin (SMA), myosin, ï?

ORGANISM(S): Mus musculus

SUBMITTER: Fariba Behbod 

PROVIDER: E-GEOD-5309 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress