Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Claus Scholz
PROVIDER: E-GEOD-53124 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Experimental cell research 20140819 2
Glioblastoma cells exhibit highly invasive behavior whose mechanisms are not yet fully understood. The present study explores the relationship between the invasion capacity of 5 glioblastoma cell lines differing in p53 and PTEN status, expression of mTOR and several other marker proteins involved in cell invasion, actin cytoskeleton organization and cell morphology. We found that two glioblastoma lines mutated in both p53 and PTEN genes (U373-MG and SNB19) exhibited the highest invasion rates th ...[more]