Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Adult ALL (Acute Lymphoblastic Leukemia)

ABSTRACT: A set of 37 BCR-ABL positive (21 and 16 of which expressed p185 and p210, respectively) and 17 BCR-ABL negative adult ALL specimens from the ECOG/MRC intergroup study E2993. Gene expression profiling was performed using the 3DNA Array 900 Expression Array Detection Kit (Genisphere, Hatfield, PA), according to the manufacturer's instructions. Universal Human Reference RNA (Stratagene, La Jolla, CA) was used as a reference RNA. The results provide insights into molecular mechanisms and pathways associated with BCR-ABL oncogenesis. Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Keywords: Logical Set Computed

ORGANISM(S): Homo sapiens

SUBMITTER: Dejan Juric

PROVIDER: E-GEOD-5314 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.

Juric Dejan D Lacayo Norman J NJ Ramsey Meghan C MC Racevskis Janis J Wiernik Peter H PH Rowe Jacob M JM Goldstone Anthony H AH O'Dwyer Peter J PJ Paietta Elisabeth E Sikic Branimir I BI

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20070220 11

<h4>Purpose</h4>To identify gene expression patterns and interaction networks related to BCR-ABL status and clinical outcome in adults with acute lymphoblastic leukemia (ALL).<h4>Patients and methods</h4>DNA microarrays were used to profile a set of 54 adult ALL specimens from the Medical Research Council UKALL XII/Eastern Cooperative Oncology Group E2993 trial (21 p185BCR-ABL-positive, 16 p210BCR-ABL-positive and 17 BCR-ABL-negative specimens).<h4>Results</h4>Using supervised and unsupervised a ...[more]

PMID: 17312329

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Dataset Information

Adult ALL (Acute Lymphoblastic Leukemia)

Publications

Differential gene expression patterns and interaction networks in BCR-ABL-positive and -negative adult acute lymphoblastic leukemias.

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