Expression data from human monocyte-derived dendritic cells treated or not with interleukin 17A (IL-17A)

ABSTRACT: IL-17A is a pro-inflammatory cytokine that promotes host defense against infections and contributes to the pathogenesis of chronic inflammatory diseases. Dendritic cells (DC) are antigen-presenting cells responsible for adaptive immune responses. Here, we report that IL-17A induces intense remodeling of lipid metabolism in human monocyte-derived DC, as revealed by microarrays analysis. In particular NR1H3/LXR-a and its target genes were significantly upregulated in response to IL-17A. IL-17A induced accumulation of Oil Red O-positive lipid droplets in DC leading to the generation of lipid-laden DC. A lipidomic study established that all the analyzed lipid species, i.e phospholipids, cholesterol, triglycerides, cholesteryl esters were elevated in IL-17A-treated DC. The increased expression

ORGANISM(S): Homo sapiens

SUBMITTER: Karene Mahtouk 

PROVIDER: E-GEOD-53163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress