Transcription profiling of mouse day 0 versus day 1 involuting mammary gland

ABSTRACT: Mammary gland involution represents one of the most dramatic examples of programmed cell death/apoptosis and tissue regression during development, yet large gaps still exist in the understanding of the mechanisms involved, and the key factors that trigger involution, are not yet identified. With the focus on identifying “novel” genes associated with mammary gland regression, we used microarray analysis to examine differentially expressed genes during early mammary gland involution in the mouse. We believe that such analysis may facilitate the identification of genes that report on proliferative changes in the breast, particularly with regards to growth arrest and growth inhibition. We further reasoned that genes that inhibit mammary gland proliferation might have relevance to breast t

ORGANISM(S): Mus musculus

SUBMITTER: Yvonne Myal 

PROVIDER: E-GEOD-5317 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress