PI3K/AKT pathway is activated by miRNA-22 in the proliferative CLL subset (mRNA)

ABSTRACT: Understanding the crosstalk between malignant B-cells and their milieu could provide clues on the molecular and clinical biology of Chronic Lymphocytic Leukemia (CLL). Aiming to generate novel therapeutic strategies, different groups have studied different CLL proliferative fractions. We previously, identified one of these proliferative subsets in the peripheral blood from progressive unmutated CLL patients. Since the presence of this small subset appears to be a hallmark of a proliferative disease in which B lymphocytes are being constitutively activated in the proliferative centers of these patients, we performed gene expression analysis comparing the global mRNA and microRNAs expression of this leukemic subpopulation. Our results suggest that the proliferative behaviour of this fraction

ORGANISM(S): Homo sapiens

SUBMITTER: Tamara Fernandez-Calero 

PROVIDER: E-GEOD-53236 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress