Transcriptomic profiling of HeLa cells infected with Salmonella Typhimurium
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Konrad Förstner
PROVIDER: E-GEOD-53280 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Functional high-throughput screening identifies the miR-15 microRNA family as cellular restriction factors for Salmonella infection.
Maudet Claire C Mano Miguel M Sunkavalli Ushasree U Sharan Malvika M Giacca Mauro M Förstner Konrad U KU Eulalio Ana A
Nature communications 20140822
Increasing evidence suggests an important role for miRNAs in the molecular interplay between bacterial pathogens and host cells. Here we perform a fluorescence microscopy-based screen using a library of miRNA mimics and demonstrate that miRNAs modulate Salmonella infection. Several members of the miR-15 miRNA family were among the 17 miRNAs that more efficiently inhibit Salmonella infection. We discovered that these miRNAs are downregulated during Salmonella infection, through the inhibition of ...[more]
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