Adult stem cells in the small intestine are intrinsically programmed with their location-specific function

ABSTRACT: Differentiation and specialisation of epithelial cells in the small intestine is regulated in two ways. First, there is differentiation along the crypt-villus axis of the intestinal stem cells into absorptive enterocytes, Paneth, goblet, tuft, enteroendocrine or M-cells, which is mainly regulated by WNT. Second, there is specialization along the cephalocaudal axis with different absorptive and digestive functions in duodenum, jejunum and ileum that is controlled by several transcription factors such as GATA4. However, so far it is unknown whether location-specific functional properties are intrinsically programmed within stem cells or if continuous signalling from mesenchymal cells is necessary to maintain the location-specific identity of the small intestine. By using the pure epithelia

ORGANISM(S): Mus musculus

SUBMITTER: Michal Mokry 

PROVIDER: E-GEOD-53297 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress