Myeloid cell expression of COMMD1 is required to restrain pro-inflammatory gene expression and tissue inflammation

ABSTRACT: Inflammation is a hallmark of multiple disease processes, including inflammatory bowel disease (IBD). The transcription factor NF-kappaB plays a critical role in this response through its effects on pro-inflammatory gene expression. Consequently, homeostatic mechanisms that control NF-kappaB activity have been found to play important roles in controlling inflammatory responses in physiologic and pathologic states. Copper Metabolism Murr1 Domain containing 1 (COMMD1), a regulator of copper excretion and other transport pathways, has been shown to play a role in limiting NF-kappaB activation. However, it remains unclear if this factor plays a necessary role in the control of inflammation or in the pathogenesis of inflammatory disorders in vivo. Using a myeloid-cell specific model of Commd1 d

ORGANISM(S): Mus musculus

SUBMITTER: Oliver Dittrich-Breiholz 

PROVIDER: E-GEOD-53368 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress