Maternal Bisphenol A effect on fetal heart and skeletal muscle gene expression

ABSTRACT: Compairsion of transcriptional profiles of heart and skeletal muscle tissue of fetal rhesus monkey exposed to maternal Bisphenol A or vehicle during early or late gestaion. Maternal exposure to the endocrine disrupting chemical, bisphenol A (BPA) affects the development of multiple organ systems in rodents and monkeys. However, effects of BPA exposure on cardiac and skeletal muscle development have not been assessed. Given that maternal BPA crosses placenta and reaches developing fetus, examining the physiological consequences of gestational exposure during development is of research significance. Therefore, we evaluate the effects of daily, oral BPA exposure of pregnant rhesus monkeys (Macaca mulatta) on the fetal heart and skeletal muscle transcriptome. Pregnant monkeys were administered

ORGANISM(S): Macaca mulatta

SUBMITTER: Matt Settles 

PROVIDER: E-GEOD-53393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress