Metabolomic heterogeneity of severe pulmonary arterial hypertension

ABSTRACT: Although multiple gene and protein expression have been extensively profiled in human pulmonary arterial hypertension (PAH), the mechanism for the development and progression of pulmonary hypertension remains elusive. Analysis of the global metabolomic heterogeneity within the pulmonary vascular system leads to a better understanding of disease progression. Using a combination of high-throughput liquid-and-gas-chromatography-based mass spectrometry, we showed unbiased metabolomic profiles of disrupted glycolysis, increased TCA cycle, and fatty acid metabolites with altered oxidation pathways in the severe human PAH lung. The results suggest that PAH has specific metabolic pathways contributing to increased ATP synthesis for the vascular remodeling process in severe pulmonary hypertension.

ORGANISM(S): Homo sapiens

SUBMITTER: Yidan Zhao 

PROVIDER: E-GEOD-53408 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress