Gene expression data from human fibroblasts and induced Pluripotent Stem cells from Parkinson's Disease patients

ABSTRACT: We have generated human induced Pluripotent Stem cells (hiPSc) from Parkinson's Disease patients, using retrovirus-mediated delivery of reprogramming factors. hiPSc lines have been screened using SNP array to assess chromosomal stability (alongside the fibroblast lines from which they derived), and validation of the pluripotency of the hiPSc lines is provided by Pluritest assessment of transcriptome datasets, prior to differentiation to dopaminergic neuronal clutures and downstream functional assays. human iPSc lines were derived from human dermal fibroblasts from 2 Parkinson's Disease patients with heterozygous glucocerebrosidase mutations (GBA N370S) mutations, and 2 idiopathic Parkinson's Disease patients. SNP datasets from the 2 control individuals used in this study have been publish

ORGANISM(S): Homo sapiens

SUBMITTER: Sally Cowley 

PROVIDER: E-GEOD-53424 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress