Narrow-band UVB phototherapy for psoriasis

ABSTRACT: Psoriasis is a common chronic inflammatory and hyperproliferative immune-mediated skin disorder. Narrow-band UVB (NB-UVB) phototherapy is a convenient first-line treatment of psoriasis, though the mechanisms underlying its efficacy have not been completely elucidated. In order to improve our understanding of NB-UVB phototherapy, gene expression profiling was used to characterize gene expression in lesional epidermis from psoriasis patients undergoing NB-UVB phototherapy. Increased expression of melanogenesis pathway genes was observed to be the earliest response. At the end of treatment, genes involved in diverse biological processes were affected, such as pigmentation, cell adhesion, ectodermal development and metabolism. The relationship between gene expression and treatment outcome was

ORGANISM(S): Homo sapiens

SUBMITTER: Xiaolian Gu 

PROVIDER: E-GEOD-53431 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress