Transcriptome analysis of 3 WT mouse lines and 3 NTD mutants with the BAF155^msp3 allele

ABSTRACT: BAF155, as a component of a chromatin remodeling complex, is thought to be involved in the regulation of gene expression. Baf155 knockdown in ES cells results in misregulation of hundreds of genes (Ho et al., 2009). The Baf155msp3 allele presents a unique case for gene expression analysis wherein the BAF complex appears to be intact, in contrast to disruption of the BAF complex when BAF155 function is lost (Chen and Archer, 2005; Sohn et al., 2007). To examine gene expression in the Baf155msp3 mutant at the time of neural tube closure, we performed RNA-Seq and compared gene expression levels between homozygous wildtype and homozygous mutant embryos. After extensive analysis of the RNA-Seq data comparing all 3 mutants to all 3 WT replicates, 78 genes were identified as being upregulated on

ORGANISM(S): Mus musculus

SUBMITTER: Lee Niswander 

PROVIDER: E-GEOD-53459 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress