Affymetrix SNP array data for dog OCD samples

ABSTRACT: Obsessive-compulsive disorder (OCD), a severe mental disease manifested in time-consuming repetition of behaviors, affects 1-3% of the human population. While highly heritable, complex genetics has hampered attempts to elucidate OCD etiology. Dogs suffer from naturally occurring compulsive disorders that closely model human OCD, manifested as an excessive repetition of normal canine behaviors that only partially responds to drug therapy. The limited diversity within dog breeds makes identifying underlying genetic factors easier. We use genome wide association of 87 Doberman Pinscher cases and 63 controls to identify genomic loci associated with OCD and sequence these regions in 8 affected dogs from high-risk breeds and 8 breed-matched controls. We find 119 variants in evolutionarily conser

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Hyun Ji Noh 

PROVIDER: E-GEOD-53488 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress